Recently, associate professor Li Li et al. of the FNU National and Local Joint Engineering Research Center of Industrial Microorganism Fermentation Technology,the College of Life Science(CLS) published aresearch paper titled “Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids”in Journal of the American Chemical Society.
The search for natural active product has always been an important research field in drug development. Byusing genome mining, LiLi et al. discoveredfrom Myceliophthora thermophilaa natural product UCS1025A thathasnovel complex trijunction heterocycle structureand strong anti-tumor activity (by inhibiting telomerase activity). Their discoveryhas not only revealed the biosynthetic mechanisms and pathways of UCS1025A at thegenetics and biochemistryleveland but also achievedefficient expression of UCS1025A in heterologous hosts through genetic engineering techniques.
The Journal of the American Chemical Societyis theflagship magazine of the American Chemical Society. A preeminentjournal in the field, it publishes the latest research results in chemistry and related interdisciplines. The most citedjournalin chemistry, it has a latest Science Citation Index impact factor of 13.858.
（Translated by Zhou QiulingReviewed byLiang Li’e）